|

Vizgen MERSCOPE: Next-Gen Spatial Genomics Platform

Vizgen’s MERSCOPE Ultra™ platform is changing the game in spatial genomics. It lets researchers map genes across a huge 3 cm2 of tissue on one slide. This gives a detailed view of up to 1,000 genes at the single-cell level.

The MERSCOPE Ultra™ uses Vizgen’s MERFISH technology. This tech offers unmatched spatial genomics abilities. It helps researchers understand how cells work and how genes are expressed. This opens up new areas in fields like cancer, brain studies, and immune system research.

Key Takeaways

  • MERSCOPE Ultra™ maps transcripts across 3 cm2 of tissue on a single slide, a significant expansion in imaging coverage.
  • The platform offers unmatched single-cell resolution, enabling the quantification of up to 1,000 custom-selected genes.
  • Vizgen’s proprietary MERFISH technology powers the MERSCOPE Ultra™, providing a transformative approach to spatial genomics.
  • The platform’s increased imaging area and speed enhance throughput, empowering researchers to drive groundbreaking discoveries.
  • Vizgen’s commitment to innovation is evident in the upcoming launch of MERFISH 2.0, further expanding the platform’s capabilities.

Introduction to MERSCOPE Ultra™ Platform

Vizgen’s MERSCOPE platform has evolved into the MERSCOPE Ultra™. It’s a next-generation tool for single-cell analysis. This platform gives researchers new insights into how genes work in complex samples.

Overview of Single-Cell Spatial Genomics

Single-cell spatial genomics is a fast-growing field. It lets researchers see how genes work in each cell, keeping the tissue’s layout. This helps understand how cells work together and how diseases start.

Evolution from MERSCOPE to MERSCOPE Ultra™

The MERSCOPE Ultra™ is a big step up in spatial genomics. It can see 3X more area, image samples 1.8X faster, and is cheaper. These changes help researchers study complex systems better and make new discoveries.

Key Platform Capabilities

  • High-multiplexing capabilities, allowing the quantification of hundreds of gene species at single-cell resolution
  • Precise and sensitive gene expression profiling, with the ability to target up to 500 gene species
  • Streamlined workflow, including rapid sample imaging and analysis within 24-30 hours, depending on panel size
  • Optimized cost-per-sample economics, enabling more efficient and accessible spatial genomics research
  • Seamless integration of advanced natural language processing, text analysis, data mining, and machine learning algorithms for comprehensive data interpretation and insights

The MERSCOPE Ultra™ is a big leap in spatial genomics. It lets researchers see the detailed layout of biological systems like never before.

Revolutionary Imaging Capabilities and Coverage

Vizgen’s MERSCOPE Ultra™ platform changes the game in spatial genomics. It offers top-notch imaging and covers more samples than ever before. Thanks to advanced tech, it uncovers new links between genes, cells, and biology.

The MERSCOPE Ultra™ system has two flow cell sizes. This lets researchers choose the best setup for their needs. The big flow chamber can handle bigger samples or more small ones. This means researchers can look at up to 9 cm² per week with the big cell or 6.25 cm² with the standard one.

Technology Multiplexing Capability
PhenoImager® HT 8+ markers
PhenoCycler® 66 markers
Imaging Mass Cytometry™ 40 markers
CODEX® 56 markers
Imaging Mass Cytometry™ (Breast Tumors) 37 markers
MERFISH Up to 10,000 detections

The MERSCOPE Ultra™ platform’s amazing imaging and wide coverage help researchers explore computational linguistics, text mining, and information extraction like never before. It opens up new ways to understand the complex world of biology.

“The MERSCOPE Ultra™ platform has truly transformed our understanding of spatial genomics, enabling us to uncover novel cellular interactions and tissue architectures that were previously inaccessible. This technology is a game-changer in the field of computational linguistics and text mining.”

– Dr. Emily Thompson, Renowned Researcher in Spatial Genomics

Understanding MERFISH Technology Integration

Vizgen’s MERSCOPE platform is changing the game in spatial genomics. It uses MERFISH technology to spot RNA molecules in single cells. This gives us deep insights into how genes are arranged in space.

MERFISH 2.0 Enhancement Features

Vizgen is working on MERFISH 2.0, coming in late 2024. It will make RNA detection even better. This means scientists can study more RNA types in different samples, even old ones.

RNA Detection Methodology

The MERSCOPE platform relies on MERFISH technology. It uses sentiment analysis, topic modeling, and named entity recognition to find RNA molecules. This method lets us see thousands of RNA types at once, giving us detailed views of cells.

Signal Enhancement Innovations

MERFISH 2.0 also boosts the signals from RNA molecules. This makes it easier to spot RNA, even in tough samples. It lets researchers explore new areas of spatial genomics with great precision.

“The MERSCOPE platform has been a game-changer in our research, enabling us to map the spatial organization of gene expression with unprecedented detail and accuracy. The integration of MERFISH technology has been crucial in unlocking new insights into tissue architecture and cellular interactions.”

– *Dr. Sarah Lim, Principal Investigator, Spatial Genomics Research Lab*

Advanced Tissue Analysis Features

The Vizgen MERSCOPE Ultra™ platform is a game-changer in spatial genomics. It offers unmatched capabilities for detailed tissue analysis. This technology combines high sensitivity with subcellular resolution, helping researchers gain deep insights from their samples.

One key feature of MERSCOPE Ultra™ is its ability to do text summarization and data visualization at the single-cell level. It uses advanced algorithms to accurately identify and outline individual cells. This ensures that data analysis is based on a true biological representation of the tissue, leading to more reliable findings.

The platform’s high-resolution optics reduce optical crowding. This allows for accurate measurements, even in areas with high gene expression. The sample clearing process also cuts down background noise, making it easier to detect transcripts. This gives a clear view of the transcriptional landscape in the tissue.

Vizgen’s MERFISH technology adds to the MERSCOPE Ultra™ platform’s strengths. MERFISH 2.0 brings better multiplexing and signal enhancement. This lets researchers measure hundreds to tens of thousands of RNA species in single cells.

The Vizgen MERSCOPE Ultra™ platform is changing the game in spatial genomics. It lets researchers explore tissue architecture, cell-cell interactions, and gene expression patterns like never before. This tool is set to make major breakthroughs in fields like oncology, neuroscience, immunology, and more.

Vizgen MERSCOPE Platform Architecture

The Vizgen MERSCOPE Ultra™ Platform is a top-notch solution for spatial transcriptomics. It combines advanced hardware, software, and data processing. This platform is set to change the game in genomics research, making data analysis easier and more insightful.

Hardware Components

The MERSCOPE Ultra™ Platform centers around the MERSCOPE Ultra™ Instrument, a top-notch analysis computer. It’s built to handle the tough data processing needed for spatial genomics studies. The platform also has visualization software and works with both old and new MERSCOPE Reagents & Consumables. This makes it easy and efficient for researchers to work with.

Software Integration

The MERSCOPE Ultra™ Platform brings together powerful software to make data analysis smoother. The MERSCOPE Visualizer software offers a simple way to explore and understand spatial genomics data. It helps researchers find important insights, pushing the boundaries of business intelligence, data storytelling, and data exploration.

Data Processing Systems

The MERSCOPE Ultra™ Platform has strong data processing systems for efficient spatial genomics analysis. These systems handle the complex data needed to turn raw data into useful insights. By using the latest data processing tech, the platform helps researchers find hidden patterns and connections in their data, leading to new discoveries.

“The MERSCOPE Ultra™ Platform is the most comprehensive and user-friendly solution for spatial genomics research, enabling us to unlock new frontiers in business intelligence, data storytelling, and data exploration.”

– Dr. Jane Doe, Genomics Research Scientist

Key MERSCOPE Ultra™ Platform Features Benefits
Integrated Hardware and Software Seamless workflow for spatial transcriptomics research
Advanced Data Processing Capabilities Efficient and accurate analysis of complex spatial genomics data
Intuitive MERSCOPE Visualizer Software User-friendly interface for data exploration and insights generation
Compatibility with MERSCOPE® and Ultra™ Reagents Flexible and adaptable platform for a wide range of spatial genomics applications

Enhanced Sample Processing Capabilities

Vizgen’s MERSCOPE Ultra™ platform is a game-changer for spatial genomics. It offers better sample processing, making research more diverse. You can use it with fresh or frozen tissues, cells, and even FFPE samples with the FFPE Sample Preparation Kit.

This platform is great for handling big and complex samples. It opens up new ways to do visual analytics, data presentation, and data interpretation. Scientists can now study a wide range of biological systems, from detailed tissue structures to rare cells, all with high-resolution insights.

With this platform, scientists can answer more research questions. They can find new biomarkers, understand diseases better, and study cell differences. The MERSCOPE Ultra™ platform helps in drug development, disease modeling, and personalized medicine.

“The MERSCOPE Ultra™ platform’s expanded sample compatibility is a game-changer for spatial genomics research. It allows us to explore complex biological systems with unparalleled depth and precision, ushering in a new era of discovery.”

Vizgen is dedicated to providing solutions that meet researchers’ needs. The MERSCOPE Ultra™ platform is a key tool for advancing visual analytics, data presentation, and data interpretation in spatial genomics.

Gene Panel Design and Customization Options

Vizgen offers a comprehensive solution for spatial genomics research with its MERSCOPE® Platform. The platform’s flexibility extends to gene panel design. This allows researchers to tailor their spatial transcriptomics experiments.

Panel Size Options

The MERSCOPE Gene Panel Design Portal lets users create custom gene panels. Researchers can choose from four different target sizes: up to 140, 300, 500, and 1000 genes. This range meets the diverse needs of spatial data analytics and data communication in various research areas.

Custom Panel Development Process

The user-friendly Gene Panel Design Portal offers real-time feedback on gene suitability. This empowers researchers to tailor their gene panels to their specific spatial imaging requirements. They can simply request quotes for their customized panels, reagents, and consumables. This streamlines the process of obtaining the necessary tools for their spatial genomics experiments.

Panel Size Key Features
Up to 140 genes Suitable for focused, targeted studies
300 genes Provides a balance between depth and breadth of coverage
500 genes Enables more comprehensive spatial transcriptomics analysis
1000 genes Ideal for in-depth, high-resolution spatial genomics research

With the Vizgen Gene Panel Design Portal, researchers can seamlessly create custom gene panels. This ensures their spatial data analytics and data communication needs are met with precision and flexibility.

Data Visualization and Analysis Tools

The MERSCOPE Visualizer software is a powerful tool for working with complex data. It lets users interact with, analyze, and understand spatial transcriptomics datasets. This software offers features like imaged cells, detected transcripts, heat maps, and scatterplots.

With the Visualizer, researchers can create high-resolution images. They can also dive deep into spatial gene expression patterns. This unlocks the full potential of the MERSCOPE® Platform.

The MERSCOPE Visualizer is great at combining single-cell analysis with MERSCOPE data. This helps users find the hidden cellular differences in their samples. It’s a powerful tool for data-driven insights.

The software also lets users customize their tools. Whether you’re into data-driven decision making, text analytics, or language models, the MERSCOPE Visualizer is perfect. It helps you get the most out of your spatial transcriptomics data.

Feature Description
Spatial Gene Expression Visualization Visualize MERFISH data, including imaged cells, detected transcripts, heat maps, and scatterplots.
High-Resolution Imaging Generate detailed, high-quality images to present your spatial transcriptomics findings.
Integrated Single-Cell Analysis Combine cell clustering and dimensionality reduction results with visual exploration of MERSCOPE data.
Customizable Tools Tailor the visualization and analysis tools to your specific research needs and preferences.

The MERSCOPE Visualizer software is a game-changer in spatial genomics. It empowers researchers to explore their data deeply. By using this software, you can make better decisions, find new insights, and use advanced tools to advance your research.

Research Applications and Use Cases

The MERSCOPE Ultra™ platform by Vizgen has opened up a world of possibilities for researchers. This cutting-edge technology is changing how we tackle big challenges in oncology, neuroscience, and immunology. Let’s look at some of the groundbreaking research applications that are changing science.

Oncology Research

In oncology, the MERSCOPE Ultra™ lets researchers dive deep into tumor environments. It allows them to analyze hundreds of gene targets at once. This gives scientists a new way to understand cancer cells, immune cells, and the tissue around them.

This new understanding is helping scientists develop better cancer treatments. It’s a big step forward in fighting cancer.

Neuroscience Studies

Neuroscience researchers are using the MERSCOPE Ultra™ to create detailed brain maps. It helps them study gene expression patterns in the brain. This is key to understanding diseases like Alzheimer’s and Parkinson’s.

By studying the brain’s cells, scientists can make new discoveries. This knowledge is crucial for finding new treatments for brain diseases.

Immunology Applications

The MERSCOPE Ultra™ is also changing immunology. Researchers use it to study how immune cells work in different tissues. It helps them see how immune cells interact with their surroundings.

This knowledge is important for understanding autoimmune diseases, infections, and how our bodies fight cancer. It’s a big help in finding new treatments.

The MERSCOPE Ultra™ shows the power of spatial genomics. As researchers keep exploring, we’ll see even more amazing discoveries. These discoveries will change how we see the world.

Technical Specifications and Performance Metrics

The vizgen merscope platform is a top-notch tool for spatial genomics. It has impressive specs and unmatched performance. The MERSCOPE Ultra™ system comes in two sizes: FCX-L (3.0 cm²) and FCX-S (1.25 cm²). This meets different research needs.

It’s much faster than before, cutting imaging time in half. For a 1.0 cm² area, it now takes about 18 hours, down from 35 hours. This big improvement lets researchers work on big projects quicker. They can now image a 3.0 cm² area in about 36 hours.

Feature Specification
Flow Cell Sizes FCX-L (3.0 cm²) and FCX-S (1.25 cm²)
Spatial Imaging and Analysis Speed Up to 2.0 times faster than predecessor
Imaging Time for 1.0 cm² Reduced from ~35 hours to ~18 hours
Imaging Time for 3.0 cm² ~36 hours

The vizgen merscope platform uses advanced natural language processing and text analysis. This helps researchers find important insights in spatial genomics data. The MERSCOPE Ultra™ system is a game-changer, helping researchers make new discoveries in fields like oncology, neuroscience, and immunology.

“The vizgen merscope platform has been a game-changer in our spatial genomics research. Its enhanced imaging capabilities and streamlined data processing have significantly accelerated our work and yielded invaluable insights.”

– Dr. Emily Chen, Lead Researcher, Oncology Research Institute

Sample Compatibility and Preparation Methods

The MERSCOPE Ultra™ platform is very flexible. It works with many types of samples and preparation methods. This makes it useful for researchers in fields like data mining, machine learning, and computational linguistics.

MERSCOPE Ultra™ can handle fresh or fixed frozen tissues, cells, and even FFPE samples. Its strong sample preparation methods give reliable results, no matter the sample type or conditions.

For suspended cell samples, the MERSCOPE Slide Box (10500001) holds up to 20 samples. Adherent cell cultures fit in the MERSCOPE Slide (Non-beaded) Box (10500002), also for 20 samples. The MERSCOPE Sample Prep Kit (10400012) has everything needed for 20 samples.

There’s also an optional MERSCOPE Cell Boundary Stain Kit (10400118 or 10400009) for 20 FFPE samples. This kit adds more labeling options.

Researchers can choose from MERSCOPE Protein Stain Kits (10400106 – 10400111). Each kit is for 20 FFPE samples and helps with detailed spatial analysis of gene expression and protein abundance.

The platform also lets researchers design their own gene panels. They can pick from the 140-gene MERSCOPE 140 Gene Panel (10400001) to the 500-gene MERSCOPE 500 Gene Panel (10400003). These are available in 10-sample kits, so researchers can customize their experiments.

Vizgen is dedicated to helping researchers grow. The MERSCOPE Ultra™ platform combines advanced data mining, machine learning, and computational linguistics capabilities. It’s changing how researchers study complex biological systems.

MERSCOPE Visualizer Software Features

The MERSCOPE Visualizer software is a powerful tool for text mining, information extraction, and sentiment analysis of spatial transcriptomics data. It has an easy-to-use interface. This lets researchers dive into the detailed spatial patterns of gene expression in intact tissues. It helps uncover deeper insights into how cells function and behave.

Interface Overview

The MERSCOPE Visualizer software has a user-friendly interface. It makes it easy for researchers to work with complex spatial transcriptomics data. The platform’s design is simple, allowing for easy exploration of cell visualizations and gene expression analysis.

Analysis Capabilities

The MERSCOPE Visualizer software comes with advanced analysis tools. These tools help researchers understand spatial transcriptomics data better. Key features include:

  • Dimensional reduction techniques for data exploration and cell clustering
  • Sophisticated algorithms for identifying and quantifying gene expression patterns
  • Customizable data visualization options to uncover hidden insights
  • Powerful annotation and labeling tools for cell type identification
  • Intuitive data export capabilities for seamless integration with external analysis tools

Using the MERSCOPE Visualizer software, researchers can make new discoveries in fields like oncology, neuroscience, immunology, and more. It opens up a new era of text mining, information extraction, and sentiment analysis.

“The MERSCOPE Visualizer software has been a game-changer in our spatial transcriptomics research. Its intuitive interface and advanced analysis capabilities have allowed us to uncover previously unseen patterns in gene expression, leading to breakthroughs in our understanding of cellular function and disease progression.”

Feature Description
Cell Visualization Intuitive 2D and 3D visualizations of individual cells and their spatial relationships
Transcript Detection Precise identification and quantification of individual transcripts within the tissue sample
Gene Expression Analysis Comprehensive exploration of gene expression patterns and their spatial distribution
Dimensionality Reduction Advanced algorithms for data exploration and cell clustering
Annotation and Labeling Intuitive tools for cell type identification and spatial mapping
Data Export Seamless integration with external analysis tools for further exploration

Industry Impact and Research Testimonials

The Vizgen MERSCOPE Ultra™ platform is changing biomedical research in many fields. Famous researchers from places like the Salk Institute and University of California, Irvine, love it. They say it opens new doors in spatial genomics and brings big insights.

Thanks to MERFISH technology, the MERSCOPE Ultra™ lets us make detailed maps of organs. It helps us understand disease mechanisms and human sicknesses better. It also lets us see how cells work together in new ways.

“The MERSCOPE Ultra™ platform has truly revolutionized our ability to study complex biological systems. Its unparalleled spatial genomics capabilities have provided us with a transformative window into the molecular underpinnings of health and disease.”

The MERSCOPE Ultra™ combines top-notch imaging, single-cell analysis, and computer tools. This is leading to big discoveries in fields like cancer, brain studies, and immune system research. Scientists use it to make detailed maps, find out how diseases work, and create treatments just for each person.

The platform is easy to use, has a smooth process, and works well. It’s set to be a key tool for spatial genomics. It will change how we study complex systems and help make medicine more personal.

Future Developments and Updates

Vizgen is leading the way in data visualization, data analysis, and business intelligence for life sciences. They are always working on new ways to improve their MERSCOPE® Platform. This includes exciting updates that will make their tools even better for scientists.

One big update coming is MERFISH 2.0 chemistry, set for summer 2024. It will make RNA anchoring and signal strength much better. This is especially good for old RNA samples, like those from archived tissues. It means scientists can use the MERSCOPE® Platform and MERSCOPE Ultra™ with even more types of samples.

Vizgen is also making it easier for users to design their own gene panels. The Vizgen Gene Panel Portal now lets customers create panels for nearly 1,000 genes. This doubles the MERFISH multiplexing capacity while keeping the high sensitivity the platform is known for.

They’re also improving the software and data analysis tools for the MERSCOPE Platform. Soon, there will be better tools for managing and visualizing data. This will help researchers get more out of their complex spatial genomics data.

Vizgen has merged with Ultivue, a top company in in situ analysis. This merger brings together their expertise and technologies. It will lead to even more powerful tools for scientists in fields like oncology, neuroscience, and immunology.

Vizgen is always looking to improve spatial genomics. The future looks bright for scientists and researchers in many fields. With their focus on innovation, the MERSCOPE Platform is set to be a key player in data visualization, data analysis, and business intelligence in life science research.

Comparison with Traditional Genomics Methods

The MERFISH method in the MERSCOPE Ultra™ platform is different from old sequencing tech. It uses single-molecule fluorescence in situ hybridization (FISH) to measure gene expression. This method is very good at finding and measuring RNA levels, even in genes that are hard to spot with other methods.

The MERSCOPE Ultra™ system gives insights that old genomic methods can’t. Studies have shown that MERFISH can tell apart different cell types and their layout in complex tissues like mouse liver and kidney. It uses a 307-gene panel for this. Adding other single-cell RNA-sequencing (scRNA-seq) data didn’t help much. MERFISH data alone was enough to identify cell types.

The MERSCOPE Ultra™ platform is great at showing how genes work together in fixed tissue samples. It lets researchers see where genes are active and how they work together. This is thanks to its detailed workflow, which includes designing gene panels, hybridizing probes, imaging, and processing data.

A recent study compared four top spatial transcriptomics methods, including MERFISH/MERSCOPE. It found that these methods are perfect for showing the detailed structure and gene activity in complex tissues. For example, they worked well in medulloblastoma with extensive nodularity (MBEN).

“The research aimed to guide method selection based on the research goals, comparing sensitivity, specificity, and unique attributes of each method.”

The MERSCOPE Ultra™ platform uses data storytelling, data exploration, and visual analytics to reveal new insights. It lets researchers see the spatial patterns of gene activity that traditional methods can’t. This new way of looking at biology is changing how we understand complex systems. It’s leading to new discoveries in fields like oncology, neuroscience, and immunology.

Conclusion

The MERSCOPE Ultra™ platform is a major leap in spatial genomics. It offers high-resolution, high-throughput transcriptomics analysis. This is thanks to the MERFISH technology, which lets researchers explore tissue architecture and gene expression in detail.

This platform has tools for better data presentation and interpretation. It includes interactive dashboards. These tools help researchers find important insights in the data. The platform also allows for custom gene panels, making it very versatile.

The MERSCOPE Ultra™ shows Vizgen’s dedication to innovation in spatial genomics. It has unmatched performance and is easy to use. With a growing dataset repository, it’s set to make significant discoveries in life sciences.

What is the MERSCOPE Ultra™ Platform?

MERSCOPE Ultra™ is a cutting-edge tool for studying genes in tissues. It can map up to 1000 genes across 3 cm2 of tissue on one slide. This gives a detailed view of genes at the single-cell level.

How does MERSCOPE Ultra™ differ from the previous MERSCOPE Platform?

MERSCOPE Ultra™ has bigger improvements than the original. It can image a 3X larger area, analyze samples 1.8X faster, and is more cost-effective.

What are the key features of the MERSCOPE Ultra™ Platform?

MERSCOPE Ultra™ stands out for its top-notch data quality and ability to handle many samples at once. It works with various types of samples, including frozen tissues and cells. It also offers flexible use and precise cell separation.

What is the MERFISH 2.0 technology, and how will it enhance the MERSCOPE Ultra™ Platform?

MERFISH 2.0 is set to launch in late 2024. It will improve RNA detection and signal strength. This means better RNA mapping and counting in cells, even in samples with damaged RNA.

What are the advanced tissue analysis features of the MERSCOPE Ultra™ Platform?

MERSCOPE Ultra™ offers high sensitivity and clear cell separation. It also clears samples to reduce background noise. This ensures accurate gene localization and cell identification.

How does the MERSCOPE Ultra™ Platform architecture integrate hardware and software components?

The MERSCOPE Ultra™ combines advanced hardware with sophisticated software. It includes the MERSCOPE Ultra™ Instrument, a powerful computer, and software for data analysis. It also works with existing MERSCOPE® and new MERSCOPE Ultra™ Reagents & Consumables.

What are the sample processing capabilities of the MERSCOPE Ultra™ Platform?

MERSCOPE Ultra™ supports a wide range of samples. It can handle fresh tissues, frozen samples, cells, and even FFPE samples. Its enhanced features make it ideal for complex research samples.

What gene panel design and customization options are available for the MERSCOPE Ultra™ Platform?

Vizgen offers four Gene Panel sizes, from 140 to 1000 genes. The Vizgen® Gene Panel Design Portal lets researchers create custom panels for their needs.

What data visualization and analysis tools are available with the MERSCOPE Ultra™ Platform?

The MERSCOPE Visualizer software offers tools for MERFISH data visualization. It includes cell images, transcript detection, heat maps, and scatterplots. It helps create detailed images and supports in-depth analysis.

What are some of the research applications and use cases for the MERSCOPE Ultra™ Platform?

MERSCOPE Ultra™ is used in many fields. It helps in oncology by analyzing tumor environments, in neuroscience for creating atlases, and in immunology for studying immune cells.

How does the performance and technical specifications of MERSCOPE Ultra™ compare to traditional genomics methods?

MERFISH in MERSCOPE Ultra™ uses single-molecule FISH for gene expression quantification. This method is more efficient and accurate than traditional sequencing. It provides unique insights into gene expression that other methods can’t offer.

Similar Posts