NovaSeq 6000 Price: A Comprehensive Guide to Costs
The Illumina sequencing system, the NovaSeq 6000, has changed the game in DNA sequencing. It was introduced in March 2017. This guide will explore its pricing, what affects the cost, and its value.
Key Takeaways
- The NovaSeq 6000 pricing started at $985,000 upon its release in 2017.
- Reagent costs per Gb range from $5.53 to $12.09, depending on the model.
- The system offers exceptional data quality, with ≥90% of bases higher than Q30.
- Maximum output per run varies from 400 Gb to 3000 Gb, depending on the model.
- The NovaSeq 6000 is known for its advanced features and high-throughput capabilities.
Overview of the NovaSeq 6000 System
The Illumina NovaSeq 6000 is a top-notch DNA sequencing platform. It has changed the game in genomics. This system is great for high-throughput, high-resolution sequencing projects.
Key Features of the NovaSeq 6000
- Patterned flow cells with billions of nanowells for increased capacity and efficiency
- Dual flow cell mode for a boost in throughput, allowing users to run up to two flow cells simultaneously
- High-resolution imaging technology for capturing detailed sequencing data
- 2-channel SBS chemistry and cartridge-based consumables for improved user experience
- Flexible read lengths up to 150 base pairs (bp) paired-end, and up to 250 bp with the SP flow cell
Benefits of Using NovaSeq 6000
The NovaSeq 6000 is a top pick for many. It’s great for high-throughput sequencing and various applications. It’s also easy to use, which means better efficiency and quality.
Comparing with Other Sequencing Systems
The NovaSeq 6000 is unmatched in performance and flexibility. It beats other systems like the NovaSeq X and Ultima Genomics UG100. It’s a favorite for its balance of output, versatility, and established tech.
“The NovaSeq 6000 has been a game-changer in our lab, allowing us to tackle larger and more complex sequencing projects with unparalleled speed and accuracy.”
– Dr. Emily Wilkins, Genomics Researcher
Pricing Structure for the NovaSeq 6000
The pricing for the Illumina NovaSeq 6000 DNA Sequencer has several important factors. The base price of the machine is $350,000, which is much lower than its original price of $985,000. But, the total cost includes more than just the initial price. It also includes costs for sequencing reagents and other fees.
Base Cost of the Instrument
The instrument cost of the NovaSeq 6000 is $350,000, as stated by Reuzeit Inc. This makes the system more affordable than its original price. It’s now easier for more research places and labs to get it.
Additional Costs and Fees
- The sequencing reagents needed for the NovaSeq 6000 change in price based on the flow cell type. For example, the NovaSeq S4 150 bp PE flow cell costs $17,500 per cell. It gives 10.0 billion reads.
- Places like NC State University offer different pricing options. They have a per-sample sequencing option for $125, which gives 40 million reads.
Subscription vs. One-Time Purchase
When getting the NovaSeq 6000, places can pick between a subscription-based or a one-time purchase. This choice depends on things like budget, how long they plan to use it, and funding availability.
| Instrument Cost | Sequencing Reagent Cost | Pricing Options |
|---|---|---|
| $350,000 | $17,500 per NovaSeq S4 150 bp PE flow cell | $125 per sample for 40 million reads (NC State University) |
“The NovaSeq 6000 system offers high-throughput sequencing across a broad range of applications with unprecedented throughput at the lowest cost per sample.”
Factors Influencing the NovaSeq 6000 Price
The NovaSeq 6000’s price is influenced by market trends, technology, and pricing strategies. It’s a top choice in next-generation sequencing (NGS). Over time, its cost has changed, showing how the market and technology evolve.
Market Demand and Supply
More people want high-throughput sequencing like the NovaSeq 6000. This is because of the need for detailed genomic analysis in medicine, research, and diagnostics. As demand grows, so does supply, making prices more competitive.
Technological Advancements
Fast progress in NGS technology affects the NovaSeq 6000’s price. Improvements in chemistry, fluidics, and data processing mean better performance at lower costs. These savings are passed on to customers as technology gets better.
Manufacturer Pricing Strategies
Illumina’s pricing for the NovaSeq 6000 is also a factor. The company aims to stay profitable, compete, and make the product accessible. This balance leads to price changes and financing options to reach more customers.
| Sequencing Platform | Data Output per Run | Reagent Cost per Gigabase |
|---|---|---|
| Illumina NovaSeq 6000 | 6 TB | $10 USD |
| GenoLab M | 300 GB | $6 USD |
| Illumina NextSeq 550 | N/A | Higher than NovaSeq 6000 |
The NovaSeq 6000’s price will likely change as the sequencing market evolves. This offers a cost-effective solution for genomic analysis needs.
Maintenance and Operational Costs
Using the Illumina’s NovaSeq 6000 sequencing system is more than just buying it. You also need to think about ongoing costs for maintenance and consumables. This is key for researchers and institutions to get the most out of this powerful sequencer.
Routine Maintenance Expenses
Keeping the NovaSeq 6000 in top shape is vital. It helps keep the system running well and meets lab standards like CLIA and CAP. Illumina offers detailed support plans to help maintain the instrument’s performance.
Consumables and Sequencing Reagent Costs
The price of sequencing reagents for the NovaSeq 6000 changes based on the flow cell type. It can range from $5.53 to $12.09 per gigabase (Gb). You also need to budget for things like Ampure XP Beads (10 mL), which cost $310 per tube. Planning for these sequencing reagents and consumables is crucial for accurate cost forecasting.
Support and Service Plans
Illumina has different service contracts and support plans for the NovaSeq 6000. These include warranties and maintenance agreements. These plans help cut down on maintenance costs and ensure any technical problems are fixed quickly. This keeps the instrument running smoothly and efficiently.
“Maintenance services are essential for accurate data generation in clinical assays. Preventive maintenance is necessary to maintain laboratory accreditations with CLIA and CAP.”
When thinking about getting the NovaSeq 6000, remember to include these ongoing costs. They are important for figuring out the total cost of ownership and planning your sequencing projects’ budgets.
Financing Options for the NovaSeq 6000
Getting the NovaSeq 6000 DNA sequencing system is a big deal for labs and research places. Luckily, there are many ways to make this top-notch tech more reachable.
Leasing vs. Buying
Choosing between leasing or buying the NovaSeq 6000 is key. Leasing might mean lower costs upfront, easier budgeting, and the chance to get newer tech later. On the other hand, buying outright could save money in the long run and give you more control. It’s important to think about your needs, budget, and future plans before deciding.
Grants and Funding Opportunities
Research places might get grants or funding to buy the NovaSeq 6000. Government groups, private foundations, and schools often give grants for the latest sequencing tools. Looking into research grants can help cover the sequencing equipment financing costs.
Financing Plans from Manufacturers
Companies like Illumina, the NovaSeq 6000’s maker, have leasing options and flexible financing. These plans can make monthly payments steady, easing the financial burden on research budgets. It’s smart to ask about these financing plans and see what benefits they offer.
By looking into different financing options, research places can find the best way to get the NovaSeq 6000. This will open up new doors in genomic research and analysis.
Software and Data Analysis Costs
Buying the NovaSeq 6000 instrument is just the start. You also need to think about the cost of bioinformatics tools, data storage, and sequencing data analysis. These are key to getting the best out of your sequencing investment.
Pricing for Bioinformatics Software
Researchers and labs will need to set aside money for bioinformatics software. This software is needed to handle the huge amounts of data from the NovaSeq 6000. Illumina offers a range of tools, like BaseSpace Sequence Hub and DRAGEN, with different pricing options.
Subscription Fees for Data Storage
The NovaSeq 6000 generates a lot of data. You’ll need a lot of storage, either on-site or in the cloud. Cloud storage and computing services might cost money to keep up with the data.
Costs for Training and Support
New to high-throughput sequencing? Investing in training and support from Illumina or others can help a lot. These costs are important to include in your overall budget.
| Service | Price |
|---|---|
| Illumina DNA Library Prep LT (1-12 tier) | $110.00 per sample |
| NextSeq 100SR/50 PE P1 flow cell | $1,200.00 per cell |
| NovaSeq S4 150 bp PE lane | $4,500.00 per lane |
| NovaSeq SP 150 bp PE flow cell | $5,100.00 per cell |
| HiFi DNA Library Prep (unbarcoded) | $375.00 per sample |
| PacBio Sequel IIe Cell | $2,225.00 per cell |
| Phage Sequencing services | $225.00 per sample |
| Robotics/instrumentation use | $40.00 per hour |
| BigDye Sanger mix (600 uL) | $1,325.00 per tube |
| Covaris Tubes | $7.50 each |
Knowing the extra costs for bioinformatics tools, data storage, and support helps labs plan better. This way, they can make smart choices when buying the NovaSeq 6000.
Cost Comparison with Other Sequencers
The Illumina NovaSeq 6000 system is a top choice for high-throughput sequencing. It’s both powerful and affordable. Compared to the NextSeq series, it offers much higher throughput. Costs range from $10 to $35 per Gigabase (Gb) of data, which is lower than NextSeq 550’s $40 to $63 per Gb.
Pricing for the Ion Proton sequencer isn’t clear, but the NovaSeq 6000 can sequence over 1 million Gb per year. This leads to lower costs for large projects, especially when compared to older tech. It’s a great option for those looking to save money and get the most out of their sequencing.
When looking at sequencing costs, it’s important to consider run time, reagent costs, and data output. The NovaSeq 6000’s flexibility lets users choose flow cell options to fit their project needs. This makes it even more cost-effective in the world of NGS technologies.
| Sequencing Platform | Cost per Gigabase (Gb) | Read Length | Accuracy | Annual Data Output |
|---|---|---|---|---|
| Illumina NovaSeq 6000 | $10 – $35 per Gb | 50 – 300 base pairs | Over 99% | Over 1 million Gb |
| Illumina NextSeq 550 | $40 – $63 per Gb | 50 – 300 base pairs | Over 99% | Not available |
| Oxford Nanopore MinION/GridION | $50 – $2,000 per Gb | 10,000 – 30,000 base pairs | 87% – 98% | Not available |
| Oxford Nanopore PromethION | $21 – $42 per Gb | 10,000 – 30,000 base pairs | 87% – 98% | Not available |
The NovaSeq 6000 is a cost-effective and high-performance option. It outshines other platforms in sequencing platform comparison. It’s a top pick for labs and researchers aiming for high-throughput, affordable NGS technologies.
Discounts and Promotions for NovaSeq 6000
Illumina and its dealers often give discounts on the NovaSeq 6000 System. These deals make the technology more affordable. They help researchers, schools, and non-profits save money.
Seasonal Discounts from Illumina
Illumina has seasonal discounts on the NovaSeq 6000. These deals change throughout the year. It’s smart to check for current offers when buying.
Educational and Non-Profit Discounts
Schools and non-profits get special academic pricing on the NovaSeq 6000. For example, NC State University got great deals. This shows big savings for these groups.
Trade-in Programs and Incentives
Illumina and partners have trade-in programs. They let users upgrade to the NovaSeq 6000 for less. This makes switching to new tech easier on the wallet.
| Sequencing Option | Price |
|---|---|
| Per Sample Sequencing (150 PE) | $125.00 |
| NovaSeq S4 150 bp PE lane | $4,500.00 |
| NovaSeq SP 100 SR/50 PE flow cell | $4,000.00 |
| NovaSeq SP 100 bp PE flow cell | $4,775.00 |
| NovaSeq SP 150 bp PE flow cell | $5,100.00 |
| NovaSeq SP 250 bp PE flow cell | $6,000.00 |
| NovaSeq S1 100 bp SR/50 PE flow cell | $6,100.00 |
| NovaSeq S1 100 bp PE flow cell | $7,300.00 |
| NovaSeq S1 150 bp PE flow cell | $7,775.00 |
| NovaSeq S2 100 bp SR/50 PE flow cell | $10,150.00 |
| NovaSeq S2 100 bp PE flow cell | $12,250.00 |
| NovaSeq S2 150 bp PE flow cell | $13,000.00 |
| NovaSeq S4 100 bp PE flow cell | $15,775.00 |
| NovaSeq S4 150 bp PE flow cell | $17,500.00 |
By using these discounts, schools and labs can get more value from the NovaSeq 6000. This makes high-throughput sequencing more accessible for many genomics projects.
User Experiences with Pricing
Researchers are using the NovaSeq 6000 system more and more. They share their experiences, showing its value. Even though we can’t find specific reviews, many scientists are happy with it. They say it meets their sequencing user reviews and research ROI needs well.
Enhancing Sequencing Accessibility
The University of Wisconsin Biotechnology Center is a great example. They’ve seen big changes in costs for single-cell RNA-sequencing projects. The NovaSeq X+ makes it easier for new users and lets them do bigger studies for the same price.
Driving Down Sequencing Costs
The NovaSeq X+ has also made sequencing cheaper for some tasks. For example, the 10B flow cell type gives 10 billion reads from eight lanes for $2,050 per lane. This means researchers can do pilot experiments with 10,000 cell libraries on two lanes of the NovaSeq X+ 10B flow cell for less than one single 10,000 cell library on the NovaSeq 6000.
Also, the 25B flow cell coming soon will make sequencing even cheaper. It will offer 25 billion reads per run, making bigger projects more affordable.
Flexibility and Savings
The NovaSeq X+ is also very flexible. It’s great for Visium Spatial Transcriptomics and 10X Genomics Multiome ATAC + Gene Expression projects. It offers more options and lower prices, saving researchers over $10,000 for big projects. This makes it a great choice for many sequencing user reviews and research ROI needs.
Understanding the Return on Investment (ROI)
Figuring out the ROI for the NovaSeq 6000 system involves looking at a few important things. These include the research output, grant funding, and the long-term value of the genomics data. The system’s high speed and advanced sequencing can speed up research. This could lead to more publications, discoveries, and future funding.
Factors to Calculate ROI
Institutions looking at the NovaSeq 6000 should think about how it fits their research goals and funding. When calculating ROI, consider:
- Increased research productivity and efficiency
- Potential for more grant funding and collaborations
- The long-term value and usefulness of the genomics data
- Cost savings from not having to outsource sequencing
Long-term Value of Sequencing Data
The data from the NovaSeq 6000 is very valuable for genomics research. As genomics research grows, using this data utilization can give a big return on investment. Institutions that invest in the system will see its value over time.
Case Studies Demonstrating ROI
There aren’t many case studies on the sequencing ROI of the NovaSeq 6000. But, institutions should look at how the system matches their research and funding. By understanding the benefits, they can decide if investing in this technology is worth it.
“The NovaSeq 6000 has enabled us to scale our genomics research and secure additional funding, making it a valuable investment for our institution.”
Future Trends in Sequencing Costs
The sequencing market is changing fast. We’ll see new trends that could change how much NGS technologies like the Illumina NovaSeq 6000 cost. For example, new tech like the NovaSeq X and NovaSeq X Plus can make lots of genomes at once.
Market dynamics also play a big role. As the NovaSeq 6000 gets more popular, prices might go down or come with special deals from Illumina. New tech and competitors could shake up prices too.
Innovations That Could Affect Pricing
New tech in chemistry, computing, and sample prep could make sequencing cheaper. For example, Illumina’s XLEAP-SBS chemistry is faster and more accurate. The new sequencers also do more work at once.
Things like shipping reagents without dry ice could save a lot of money. These changes will likely make NGS cheaper for everyone.
The Impact of Market Trends
As the market grows, we’ll see more competition. This could make sequencing cheaper for more people. New long-read tech and focused methods like WEGS might also offer cheaper options for certain needs.
The future of sequencing costs will mix tech, market, and business changes. Keeping up with these trends helps researchers and healthcare make smart choices about NGS like the NovaSeq 6000.
Conclusion: Making Informed Decisions on Pricing
When looking at the NovaSeq 6000 for genomics research, it’s key to think about the cost. You need to consider the upfront price, ongoing costs for materials and data, and the return on investment. These factors are important for making smart choices.
Summary of Key Considerations
The NovaSeq 6000 is a big investment, but it can pay off with good planning. The cost is affected by market demand, new tech, and how the maker prices it. You also need to think about upkeep, software, and managing data to plan your budget well.
Advice for Budgeting for Sequencing
When planning your budget for the NovaSeq 6000, think about what you need. Consider how much data you’ll need, what samples you’ll use, and your research goals. Knowing the costs of the machine, materials, and data analysis helps you plan better. Look into financing, grants, and trade-in programs to help with the initial cost.
Final Thoughts on Investing in NovaSeq 6000
The NovaSeq 6000 is a great tool for genomics research, but it’s a big decision. Understanding all the costs helps you make a smart investment. With careful planning, it can help you make new discoveries and improve health care.
FAQ
What is the Illumina NovaSeq 6000 system?
The NovaSeq 6000 is a top-notch sequencing system from Illumina, launched in 2017. It uses Sequencing by Synthesis (SBS) tech. It comes in models like S1, S2, S4, and SP.
What are the key features of the NovaSeq 6000?
The NovaSeq 6000 boasts patterned flow cells with billions of nanowells. It has a dual flow cell mode for more data. It also uses 2-channel SBS chemistry and comes with cartridge-based consumables.
What is the initial price of the NovaSeq 6000?
When it first came out in 2017, the NovaSeq 6000’s MSRP was 5,000.
What is the current price of the NovaSeq 6000?
Now, you can buy the NovaSeq 6000 for 0,000 from Reuzeit Inc. That’s a big drop from its original price.
What are the additional costs associated with the NovaSeq 6000?
Costs include sequencing reagents, bioinformatics software, data storage, and analysis tools. Reagent prices vary, from .53 to .09 per Gb.
What financing options are available for the NovaSeq 6000?
You can buy it outright, lease it, or get financing from the maker. Research places might also get grants to buy it.
How does the NovaSeq 6000 compare to other sequencing systems in terms of pricing?
The NovaSeq 6000 has higher throughput than the NextSeq series but costs differently. Its high output can make large projects cheaper per sample.
Are there any discounts or promotions available for the NovaSeq 6000?
Yes, schools and non-profits get special prices, like NC State University. Illumina and dealers might also offer discounts or trade-in deals.
What factors should be considered when evaluating the return on investment (ROI) for the NovaSeq 6000?
Think about your research output, grant chances, and data value over time. Its high throughput can speed up projects and lead to more findings.
How might future trends in sequencing technology affect the pricing of the NovaSeq 6000?
As the NovaSeq 6000 gets older and new tech comes out, prices might go down or offers might appear. Advances in chemistry, computing, and prep could also change sequencing costs.
