Eurofins Genomics Sequencing
Eurofins Genomics stands as a beacon in the world of DNA sequencing and genomic services. With a legacy spanning nearly four decades, this industry leader has been at the forefront of reading and writing DNA for researchers worldwide1. Their extensive portfolio caters to diverse sectors, including molecular diagnostics, academics, and pharmaceutical research1.
The company’s expertise shines through its wide-ranging offerings. From DNA/RNA synthesis to cutting-edge Nanopore and Sanger sequencing, Eurofins Genomics delivers top-notch solutions for every genomic need1. Their whole-genome sequencing capabilities cover all DNA types in an organism, ensuring comprehensive genetic analysis2.
What sets Eurofins apart is their commitment to innovation and customer satisfaction. They handle millions of assays annually, backed by state-of-the-art facilities and a team of dedicated experts1. Whether it’s de novo sequencing for newly discovered organisms or re-sequencing for genetic variation studies, Eurofins has the tools and know-how to deliver accurate results2.
Researchers praise Eurofins for their quality, competitive pricing, and quick turnaround times1. With user-friendly collaboration tools and specialized products like the INVIEW Human Exome, Eurofins Genomics continues to push the boundaries of genomic research12.
Key Takeaways
- Eurofins Genomics boasts nearly 40 years of DNA sequencing expertise
- Offers a wide range of genomic services, from synthesis to sequencing
- Provides solutions for various industries, including academics and pharma
- Handles millions of assays annually with high-quality results
- Specializes in both de novo and re-sequencing techniques
- Known for competitive pricing and fast turnaround times
- Offers innovative products like the INVIEW Human Exome
Introduction to Eurofins Genomics Sequencing
Eurofins Genomics stands at the forefront of genomic services, offering a wide array of solutions for researchers and scientists. Their commitment to quality and innovation has made them a trusted partner in the field of DNA synthesis, RNA synthesis, and sequencing services.
Overview of the Company
Eurofins Genomics has established itself as a leader in genomic research support. They provide cutting-edge sequencing technologies, including the Illumina NovaSeq 6000 platform for high-throughput sequencing. This system supports single-read and paired-end sequencing with read lengths up to 2 x 250 bp, enabling versatile options from single cells to full populations3.
Key Services Offered
Eurofins Genomics offers a comprehensive suite of services tailored to meet diverse research needs:
- DNA and RNA synthesis
- Next-Generation Sequencing (NGS)
- Sanger sequencing
- Gene synthesis
- Probes and primers
Their NGS services cater to projects of all sizes, even accommodating single sample requests. For those new to NGS, Eurofins provides 60 minutes of personalized consulting, demonstrating their dedication to customer support3.
Eurofins excels in both de novo genome sequencing for novel genomes and re-sequencing projects when a reference sequence is available. Their expertise extends to assembly of shotgun reads into contigs based on sequence identities for de novo projects4.
To ensure convenience and flexibility, Eurofins offers various plate sequencing options. These include PrePaid Plates for grant-funded labs, ShortSeq Plate for faster, lower-cost sequencing, and Ready2Load Plate for pre-cycled samples. Their PlateSeq Service provides full sequencing for plasmids and PCR products with customizable options5.
Importance of Genomic Sequencing
Genomic sequencing has become a cornerstone in advancing medical research and personalized medicine. Its applications span from identifying specific biological markers to developing targeted therapies. The field has seen remarkable growth, with numerous studies focusing on various aspects of sequencing technology.
Applications in Medical Research
In recent years, genomic sequencing has played a crucial role in medical research. Studies have covered a wide range of topics, from comparative transcriptome analysis to draft genome sequences. In 2021 alone, 26 studies related to sequencing data were conducted, while 2022 saw 19 studies focusing on areas like microbial community analysis and blood transcriptomics during hibernation6.
Genetic analysis through sequencing has opened new avenues in understanding diseases and developing treatments. For instance, DNA methylation analysis for cancer detection and metagenome sequencing for identifying sourdough microbiota were among the nine specialized studies conducted in 20236. These advancements highlight the growing importance of genomic sequencing in medical research.
Role in Personalized Medicine
Personalized medicine has greatly benefited from genomic sequencing technologies. The ability to customize oligonucleotides for sequencing workflows by adjusting length, sequence specificity, and chemical modifications has revolutionized targeted treatments7. This customization allows for more precise and effective medical interventions tailored to individual genetic profiles.
The impact of genomic sequencing on personalized medicine is evident in recent studies. In 2024, researchers examined gut microbiota alteration in psoriasis patients and the effects of brodalumab on the fungal microbiome, showcasing how genetic analysis can inform treatment strategies6. With rapid turnaround times – as quick as 2 business days for bacterial genome sequencing – healthcare providers can make faster, more informed decisions about patient care8.
Types of Sequencing Services Offered
Eurofins Genomics provides a range of cutting-edge sequencing services to meet diverse research needs. From traditional methods to advanced technologies, they offer solutions for various genomic projects.
Next-Generation Sequencing (NGS)
NGS technology has revolutionized genomic research. Eurofins Genomics offers NGS services for complex projects, including de novo sequencing and re-sequencing. These services are ideal for novel genomic sequences and mapping shotgun reads to reference sequences4.
Sanger Sequencing
Sanger sequencing remains the gold standard for many applications. Eurofins Genomics’ Sanger sequencing boasts a 97.3% success rate with 99.999% accuracy9. It’s available for research use, GLP, and GMP applications, making it versatile for various needs.
Nanopore Sequencing
For rapid and cost-effective sequencing of whole plasmids, linear/amplicons, and bacterial genomes, Eurofins Genomics offers Nanopore sequencing. This technology provides fast results for smaller-scale projects.
| Service | Accuracy | Applications |
|---|---|---|
| NGS | High | Complex genomic projects, de novo sequencing |
| Sanger | 99.999% | Research, GLP, GMP applications |
| Nanopore | Moderate to High | Rapid sequencing of smaller genomes |
Eurofins Genomics stands out as the fastest nationwide sequencing provider, surpassing competitors in quality benchmarks for read length and Q20 score9. They offer prepaid sequencing options and are the only US provider delivering nationwide overnight results by 10 AM on the day samples arrive9.
Quality Control Measures
Eurofins Genomics sets the gold standard in quality assurance for genomic sequencing. Their commitment to excellence is evident in their rigorous quality control measures, ensuring top-notch results for researchers and clinicians alike.
Ensuring Accurate Results
Eurofins Genomics pioneered 100% Mass Spectrometry (MS) testing for oligonucleotides in 1998, setting a new benchmark for accuracy10. They employ cutting-edge techniques like Analytical Reverse-Phase HPLC and Ion-exchange HPLC pH 12.0 for DNA & RNA analysis at all scales10. Capillary electrophoresis is used to measure the percentage of full-length product, guaranteeing precision in every sequence10.
Validation and Verification Processes
Eurofins Genomics is one of the few labs in the United States with both GLP and GMP accreditations, demonstrating their dedication to quality11. Their GMP Sequencing service includes rigorous quality control at every step, ensuring reliability for non-clinical customers in academic and commercial sectors11. Comprehensive documentation practices are maintained for all procedures, reagents, equipment, and personnel, essential for regulatory compliance and audit purposes11.
| Quality Control Measure | Description | Benefit |
|---|---|---|
| Mass Spectrometry Testing | 100% MS testing for oligonucleotides | Enhanced accuracy in sequence analysis |
| HPLC Analysis | Reverse-Phase and Ion-exchange HPLC | Precise DNA & RNA analysis at all scales |
| Capillary Electrophoresis | Measures full-length product percentage | Ensures sequence integrity |
| GMP/GLP Accreditation | Dual accreditation in GLP and GMP | Highest industry standards compliance |
By adhering to GLP standards and GMP compliance, Eurofins Genomics ensures data security, confidentiality, and expert support throughout the sequencing process. Their quality assurance measures provide researchers with reliable, accurate results and peace of mind for regulatory sequencing projects.
User-Friendly Interface
Eurofins Genomics offers a user-friendly online platform that simplifies the research process. Their interface caters to various needs, from oligo design to sequencing data management.
Online Access to Results
The online platform provides quick access to genomic and clinical datasets. Researchers can easily manage whole genome sequencing, transcriptomics, and exome sequencing data12. The web-based user interface allows for seamless browsing and efficient data retrieval, extracting meaningful insights within seconds12.
Eurofins Genomics’ database tools enable swift updates, additions, and removals of information. This flexibility ensures that researchers can customize their data organization to fit specific research goals12.
Sample Submission Guidelines
The user interface streamlines the sample submission process. Researchers can access clear guidelines for preparing and sending samples. The SimpleSeq™ Prepaid Sequencing Kits offer a cost-effective option, with 96% of results delivered the same day samples arrive at the lab13.
| Kit Type | Price | Features |
|---|---|---|
| SimpleSeq Kit | $554.40 | Standard sequencing kit |
| SimpleSeq Premixed Kit | $498.75 | Pre-prepared samples |
| FlexReads Refill | $31.50 | For topping up existing kits |
The platform provides comprehensive support for users. Technical assistance is available via phone and email during extended business hours, ensuring researchers can get help when needed13. This user-centric approach makes Eurofins Genomics a reliable partner for genomic research projects.
Custom Solutions for Researchers
Eurofins Genomics stands out in the field of custom sequencing by offering tailored solutions that cater to diverse research needs. Their approach to custom sequencing packages and research collaboration sets them apart in a rapidly growing market.
Tailored Sequencing Packages
Eurofins Genomics Blue Heron has been at the forefront of gene synthesis since 1999, delivering millions of base pairs of accurately synthesized genes worldwide14. Their GeneMaker platform enables the synthesis of nearly any gene, including complex DNA with challenging elements like hairpins, repeats, and GC-rich regions14. This capability allows researchers to access custom sequencing solutions that fit their specific project requirements.
Collaboration on Research Projects
Eurofins Genomics has built a strong reputation for research collaboration across various industries. Their services have been utilized by top 20 pharma and biotech companies, highlighting their expertise in tailored solutions for high-level research14. This collaborative approach is crucial in a market where universities and research entities accounted for nearly 53% of the total revenue in 2023 in the next-generation sequencing services sector15.
The company’s commitment to custom sequencing and research collaboration is evident in their accreditations. Eurofins is licensed to operate in all 50 states and holds CLIA, CAP, and NYCLEP accreditations, ensuring high-quality standards across their tailored solutions16. This level of expertise and flexibility is essential in a market projected to grow at a CAGR of 22.39% from 2024 to 2030, with the U.S. next-generation sequencing services market estimated at USD 2.48 billion in 202315.
Data Analysis Services
Eurofins Genomics excels in data analysis services, offering cutting-edge solutions for researchers. Their comprehensive approach combines sequencing with advanced bioinformatics support, enabling scientists to unlock the full potential of genomic data.
Bioinformatics Support
The company’s bioinformatics team uses the latest tools and software to deliver data in optimal formats for further analysis or scientific publications17. With over six years of experience in genomic and cDNA library preparation, Eurofins Genomics brings deep expertise to every project17. Their services cover a wide range of applications, including gene expression profiling, de novo assembly of cDNA reads, and mutation detection in expressed genes18.
Interpretation of Sequencing Data
Eurofins Genomics offers robust data interpretation services. These include mapping reads onto reference genomes, expression analysis through read counting, and optional differential expression analysis using up-to-date statistical models18. Researchers receive comprehensive deliverables, such as FASTQ files, mapping survey results, and deep data interpretation, enabling thorough genomic analysis18.
For those needing assistance, Eurofins provides technical support on weekdays, ensuring researchers can maximize the value of their sequencing data1817. This commitment to customer service, combined with their DNA Campus network, positions Eurofins Genomics as a leader in bioinformatics and data interpretation for genomic research17.
Case Studies and Success Stories
Eurofins Genomics has made significant strides in genomics applications, showcasing their research impact through innovative projects. Their advanced sequencing methods have revolutionized various fields, from medical diagnostics to environmental studies.
Innovative Research Supported by Eurofins
In 2014, Eurofins Genomics developed a groundbreaking methodology using whole genome sequencing, demonstrating that rare mutations occur early in the embryonic stage during cell division19. This innovative approach led to a new test based on embryonic genetic mutations, which successfully determined paternity in a case involving identical twin potential fathers19.
Another notable achievement was Eurofins’ quick and successful outcome in a criminal case involving identical twins. Using saliva samples and crime scene evidence, they employed ultra-deep Next Generation Sequencing to analyze genetic information and detect specific mutations19.
Eurofins has also contributed to viral research, comparing first-, second-, and third-generation sequencing platforms for Usutu virus (USUV). Their study focused on samples isolated from various matrices, organs, and blood cruor from birds collected throughout Germany20. This research has significant implications for understanding USUV lineages and their distribution across Europe.
Client Satisfaction and Testimonials
Researchers praise Eurofins for their fast turnaround times and high-quality results. The company’s commitment to excellence is evident in their continuous improvement efforts. They’ve reduced test costs by 50% through advanced chemistry and process improvements, enhancing client satisfaction19.
Eurofins’ expertise in genomics applications has been crucial in easing the implementation of future phylogeographic and phylodynamic USUV studies. Their comparison of sequencing platforms, including Sanger, Illumina, and MinION Nanopore technologies, has provided valuable insights for researchers20.
Competitive Pricing and Flexibility
Eurofins Genomics leads the pack with affordable sequencing options tailored to diverse research needs. Their pricing structure balances quality and cost-effectiveness, making advanced genomic services accessible to a wide range of researchers.
Cost-Effective Sequencing Options
Eurofins offers a variety of budget-friendly sequencing choices. Their standard Sanger Sequencing service is priced at $8.95, while custom primer synthesis costs the same21. For those needing specialized services, Nanopore Sequencing QC is available for $15.00, and Endotoxin testing with LAL test is offered at $350.0021.
Customers praise Eurofins for their competitive pricing options. One reviewer noted, “The prices are really competitive,” highlighting the company’s commitment to affordability22. With an average rating of 4.0 out of 5.0 based on 7 reviews, Eurofins has earned trust in the scientific community22.
Bulk Pricing for Large Projects
For larger projects, Eurofins provides bulk pricing options. Their Standard Midi Scale Plasmid Prep costs $100.00, while the Standard Maxi Scale Plasmid Prep is priced at $150.0021. Researchers can benefit from economies of scale, reducing costs for extensive sequencing work.
Eurofins Genomics Blue Heron, dedicated solely to gene synthesis in the USA for over two decades, offers additional value. They provide free DNA archiving for every gene and vector, along with over 100 IP free expression vectors23. This combination of affordable sequencing, bulk discounts, and value-added services makes Eurofins a top choice for genomics research.
Future of Genomic Sequencing
The landscape of genomic sequencing is rapidly evolving, with emerging technologies reshaping the field. Nanopore sequencing stands out as a game-changer, allowing direct reading of DNA or RNA at the molecular level24. This innovative approach finds applications in clinical diagnostics, genetic research, environmental studies, and pandemic surveillance24.
Emerging Technologies
Nanopore sequencing offers numerous advantages, including ultra-long reads, real-time sequencing, and portability24. These features make it a versatile tool for various genomic advancements. The T20 ultra-high throughput sequencer has dramatically reduced costs, enabling large-scale genomic projects at under $100 per genome25.
Eurofins’ Role in Advancing Genomics
Eurofins Genomics is at the forefront of these future trends in sequencing technology. Their partnership with MGI Tech combines resources from over 55,000 Eurofins Genomics employees and 2,900 MGI professionals, enhancing capabilities in genomics research and clinical applications25. This collaboration has led to significant advancements, with Eurofins Genomics offering a comprehensive portfolio of over 200,000 analytical methods25.
The impact of these genomic advancements is evident in the scientific community. More than 6,800 papers have been published in prestigious journals, highlighting the role of new sequencing technologies in life science research and precision medicine25. As we look to the future, Eurofins Genomics continues to drive innovation, shaping the next era of genomic research and applications.
Conclusion: Why Choose Eurofins Genomics Sequencing
Eurofins Genomics stands out as a top choice for reliable sequencing services. Their state-of-the-art labs, equipped for DNA and RNA extraction, showcase their commitment to quality and research support26. With a track record of handling large multinational projects, they offer the genomics expertise needed for cutting-edge research.
Commitment to Quality and Research
The company’s dedication to excellence is evident in their GLP-certified and ISO 17025 accredited NGS labs26. They provide a wide range of sequencing options, from de novo genome sequencing to re-sequencing projects, with turnaround times of 6-8 weeks for most projects27. Their gold standard method for bacterial and fungal genome sequencing combines backbone sequencing with scaffolding, reducing post-sequencing efforts27.
Advancing Genomic Research
Eurofins Genomics has played a key role in advancing genomic research. Their work has led to discoveries in various fields, including periodontitis in cirrhosis patients and the impact of barley products on microbiota composition in rats26. They’ve also supported studies on lignin biosynthesis and the resistome of arugula, showcasing their versatility in research support26.
In the evolving field of genomics, where sequencing the human genome once took years and cost $70 million, Eurofins Genomics utilizes next-generation sequencing platforms that can generate a terabyte of data in about six days28. This rapid progress in technology, combined with Eurofins’ expertise, makes them an ideal partner for researchers seeking reliable sequencing and comprehensive genomics expertise.
Q&A
What services does Eurofins Genomics offer?
Eurofins Genomics offers a wide range of genomic services including DNA/RNA synthesis, probes, Nanopore sequencing, Sanger sequencing, and gene synthesis. They also provide next-generation sequencing (NGS) solutions for more complex genomic projects.
How experienced is Eurofins Genomics in the field?
Eurofins Genomics has nearly 40 years of experience in reading and writing DNA, making them a trusted global leader in life science products and services.
What quality standards does Eurofins Genomics comply with?
Eurofins Genomics complies with GMP, GLP, and ISO quality assurance standards, ensuring the highest level of accuracy and reliability in their services.
What types of sequencing does Eurofins Genomics offer?
Eurofins Genomics offers various sequencing services including Sanger sequencing (considered the gold standard), Nanopore sequencing for fast and affordable whole plasmid and bacterial genome sequencing, and next-generation sequencing (NGS) for complex genomic projects.
How does Eurofins Genomics support data analysis?
Eurofins Genomics provides comprehensive data analysis services, including bioinformatics support to help researchers interpret complex sequencing data. They offer analysis tools for primer and assay design, as well as support for interpreting results from various sequencing methods.
Does Eurofins Genomics offer custom solutions?
Yes, Eurofins Genomics offers custom-tailored solutions to fit client parameters. They provide personalized sequencing packages and collaborate on various research projects across different fields, ensuring flexibility and adaptability to meet specific research needs.
How user-friendly is Eurofins Genomics’ platform?
Eurofins Genomics provides a user-friendly interface with online tools for oligo design, sequencing dashboards, and collaboration features. Their My Groups tool allows users to share data, resources, and results on projects automatically, ensuring a smooth and efficient experience for researchers.
What industries does Eurofins Genomics serve?
Eurofins Genomics caters to diverse industries including molecular diagnostics, academics, genomics, infectious disease, life sciences, clinical research, agro science, and pharmaceuticals.
How does Eurofins Genomics ensure competitive pricing?
Eurofins Genomics offers a range of cost-effective sequencing options, including prepaid sequencing kits and bulk pricing options for larger projects. Their pricing structure is designed to provide value while maintaining high-quality standards.
What role does Eurofins Genomics play in advancing genomic research?
Eurofins Genomics is at the forefront of genomic sequencing advancements, continually incorporating emerging technologies into their service offerings. They play a significant role in advancing genomics through their commitment to innovation, research support, and the development of new sequencing technologies.
